Rabbit Anti-Carbamyl-Lysine (CBL) Polyclonal Antibody, 50 ug
Product details
Background
Carbamylation is a post-translational modification which occurs throughout the lifespan of proteins in
vivo. Carbamylation results from the binding of isocyanic acid, spontaneously derived from high
concentrations of urea and leading to the formation of carbamyl-lysine (CBL). The carbamylation of
proteins is usually associated with a partial or complete loss of protein function. It is known that elevated
urea directly induces the formation of potentially atherogenic carbamylated LDL (cLDL). High blood
concentrations of urea leading to the carbamylation process were detected in uremic patients and patients
with end-stage renal disease.