Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004).
Physical State: Liquid; Buffer contents: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50% glycerol.
Storage/Stability: Stable at -20 °C for at least 1 year. For long term storage -20 °C is recommended
Purification Method:
Prepared from rabbit serum by affinity purification using a protein A column and using a column to which the immunogen was coupled.